Here is a list of usefull hotkeys that I use nearly every day:
Windows button+r = brings up the 'run' window
Alt+F4 = Close a window, or an application, brings up the shutdown screen if on desktop.
Alt+Tab = Cycle through open applications.
Windows button+m = Minimize all apps. VERY useful for instantly getting to your desktop!
Windows button+f = Find files/programs on your computer.
When you are in your browser you can use Ctrl+F and then type something to find that specific word on that page.
You can also hold Ctrl and scroll up/down to zoom in/out
And last but not least we have the most common shortcut that everyone should know how to use:
Copy the file/text CTRL + C
Paste the file/text CTRL + V
Cut the file CTRL + X
Undo CTRL + Z
Reverse last Undo action if possible CTRL + Y
Thanks for reading!